Higuchi connors phase solubility techniques
The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1
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Abstract The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability.Phase Solubility Studies. These studies were performed to select the stoichiometry of FLF - β-CD and FLF - β-CD - Soluplus® using the described method by Higuchi-Connors . Briefly, different concentrations of β-CD solutions (2–12 mM) were prepared, and an excess quantity of FLF was added to the solution.Derived from the slope of the linear phase solubility diagram, the apparent stability constant ... (25–100 mM), as described by Higuchi and Connors (1965). After shaking for 48 h at 37 °C ± 1 °C in a shaking water bath to reach equilibrium, samples were collected in triplicate and subsequently filtered through a 0.45 μm polyvinylidene ...Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...The influence of both temperature and CYD concentration on complex solubility was studied using the method of Higuchi and Connors (Adv. Anal. Chem., 4 (1965) 117–212). This is based on monitoring changes in the solubility of substrate (salbutamol) on the addition of complexing agents (α-, β-, Me-β- and γ-CYD).The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...Phase solubility of FA/HP-β-CD complex. Phase solubility studies were carried out according the method described by Higuchi and Connors’s methods (1965). Excess amounts of FA were added to 10 ml of water solution of HP-β-CDs at different concentrations ranging from 0 to 8.5 mM.Higuchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 11, Folder: 35. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer …PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique. Research J. Pharm. and Tech. 2020; 13(10):4557-4564. doi: 10.5958/0974-360X.2020.00803.3 Cite(Electronic): Gaurav Bhaduka, Jitendra Singh Rajawat. Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique.T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Phase solubility test was performed according to the method of Higuchi and Connors . An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …Solubility diagrams were obtained according to Higuchi and Connors. 11 . Excess ... Phase solubility techniques, in: C. Reilly (Ed.), Advances in. Analytical ...
Phase solubility techniques. T. Higuchi, A. Connors. Published 1965. Chemistry. No Paper Link Available. Save to Library. Create Alert. Cite. 2,644 Citations. Citation Type. More Filters. Environmentally friendly stability-indicating HPLC method for the …The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution ...
[Article] - Phase Solubility Techniques . I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv. Anal. Chem. Instrum. 4, 117-212. comment sorted by Best Top New Controversial Q&A Add a …PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. …
Reader Q&A - also see RECOMMENDED ARTICLES & FAQs. The phase solubility curve can be classified as an A L-type diagra. Possible cause: The apparent solubility of the substrates (adenine, guanosine, acyclovi.
The solubility of hydrocortisone (HC) was measured in water containing varying concentrations of γCD. The resulting B S-type phase-solubility diagram was described within the theoretical framework laid out by Higuchi and Connors. The initial linear increase in the solubility at low concentrations of γCD was caused by the formation of a water ...In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …
Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.Solubility diagrams were obtained according to Higuchi and Connors. 11 . Excess ... Phase solubility techniques, in: C. Reilly (Ed.), Advances in. Analytical ...
The apparent solubility of the substrates (adenine, guano Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).The phase solubility diagram (Fig. 2) showed that the solubility of cholesterol increased linearly with increasing β-CD concentration from 0 to 18 mmol/L (R 2 > 0.99). The phase solubility diagram was defined as the A L -type phase based on the early research of Higuchi and Connors (1965) , revealing the formation of inclusion complex … Phase solubility studies. Degree of complexatioHiguchi T, Connors AK. Phase solubility techniques. In: Re Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article. Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride.Phase solubility studies. The impact of the presence of BCD on the aqueous solubility of propolis extract was measured at different temperatures. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Saturated solution of BCD (15 mM) was prepared, heated at 50 °C and shaken until complete ... The apparent stability constant of the KET- BC In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant … also calculated whe re possible accordin g to HiguchiThe phase solubility diagrams for curcumin/cyclodextriPhase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： The effect of β-CD on the solubility of atorvastatin was investigated according to the phase solubility technique reported by Higuchi and Connors . Excess amounts of atorvastatin were added to 20 mL of either double-distilled water or aqueous solutions containing increasing concentrations of CDs, ranging from 5 to 15% w/w, in a …One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. There is no author summary for this article yet. Authors can ad In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations. There is no author summary for this article yet. Aut[Phase solubility studies. Degree of complexation between nanosponges aThe apparent solubility of the substrates (adenin Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.