Janine l. kwapis

Janine L Kwapis; Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during ...

Oct 11, 2019 · Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process and adaptation of fear for each avoidance behavior ... Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. WoodBrief Communication NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning Marieke R. Gilmartin,1 Janine L. Kwapis, and Fred J. Helmstetter Department ofThis work was supported by grants from the US National Institutes of Health (DA025922, DA036984 and MH101491 to M.A.W.), the National Institute of General Medical Sciences of the National Institutes of Health (GM055246 supporting A.O.W. and A.J.L.), the Department of Education GAANN (P200A120165 supporting A.O.W. and A.J.L.), the US …1. To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory ConsolidationDeletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

Christopher W. Butler, 1 Ashley A. Keiser, 1 Janine L. Kwapis, 2 Nicole C. Berchtold, 1 Vanessa L. Wall, 1 Marcelo A. Wood, 1 and Carl W. Cotman 1 Christopher W. Butler 1 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92617, USA Janine L Kwapis 1 , Timothy J Jarome, Marieke R Gilmartin, Fred J Helmstetter Affiliation 1 Department of Psychology, University of Wisconsin-Milwaukee, 2441 Hartford Ave., Milwaukee, WI 53211, USA.Janine L. Kwapis Neuropsychopharmacology (2023) Mapping the spatial transcriptomic signature of the hippocampus during memory consolidationDr. Diane Rhee, MD is a psychiatrist in New York, New York. Dr. Rhee is on Doximity. As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.Graham D. L. et al. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 10, 1029-1037 (2007). [Google Scholar] Graham D. L. et al. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 65, 696-701 (2009).If updating can reorganize the trace memory so that it relies on the delay circuit, after the memory restabilizes, the amygdala should be required for extinction (Kwapis et al, 2014a) and the RSC should no longer be involved in memory retrieval (Kwapis et al, 2014a; Kwapis et al, 2015b). Thus, we can test whether reconsolidation-dependent ...

Jun 6, 2019 · This work was supported by National Institutes of Health Grants MH101491, AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the National Institute on Aging. We thank Dr. Timothy Bredy for his help developing the HA-Nr4a1 virus. Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Woodselect article Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorderJanine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Metrics and citations Metrics

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Janine Karbowski, Kanine Karbowski, Janine Lynn Karbowski, Janine L Kwapis, Janine L Karbowski. 989-***-**** View Phone. 11 Visits. Photos. LOW HIGH. 0 Add Rating Anonymously. 0 Reputation Score Range. 2.21 4.08 /5. View Actual Score Check Background This ...Added Creator Janine L. Kwapis November 15, 2021 13:11 by Researcher Metadata Database. Published November 15, 2021 13:11 by Researcher Metadata Database. Updated February 28, 2022 22:44 ...Janine L. Kwapis et al. J. Neurosci. 2019;39:4999-5009 ©2019 by Society for Neuroscience Hippocampal overexpression of Nr4a1, Nr4a2, or both transcripts enhances OLM. A, Experimental design. Janine L. Kwapis et al. J. Neurosci. 2019;39:4999-5009 ©2019 by Society for Neuroscience Behavioral characterization of young, AU, and AI rats. ...Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).Nicole C. Ferrara 1,2, Janine L. Kwapis 3 and Sydney T rask 4,5 * ... Kwapis and Wood, 2014), suggesting plasticity in. Frontiers in Synaptic Neuroscience 02 frontiersin.org. fnsyn-15-1146665 Fe ...Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this author. Destiny S. Wright, Destiny S. Wright.

The Neuroscience section of the Current Protocols journal covers research methods involving molecular pathways, synaptic transmission, behavioral techniques & imaging.Janine L. Kwapis: Conceptualization, Writing – original draft, Writing – review & editing, Supervision, Funding acquisition. Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodJanine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter Biology Research output: Contribution to journal › Article › peer-review 64 Scopus citations Overview Fingerprint Abstract The retrosplenial cortex (RSC) is known to play a role in the ...Janine L. Kwapis, PhD THE PAUL BERG EARLY CAREER PROFESSOR IN THE BIOLOGICAL SCIENCES; Assistant Professor of Biology. [email protected]. My research focuses on understanding the epigenetic and molecular basis of long-term memory. I'm particularly interested in understanding how these mechanisms are altered in the aging brain and how epigenetic ...It is established that CAMKII is active within the perirhinal region between ∼20 and 100 min following learning and then returns to baseline, which is essential for the consolidation of long‐term object recognition memory. The aim was to investigate the role of calcium‐calmodulin‐dependent protein kinase (CAMK)II in object recognition memory.AU - Kwapis, Janine L. AU - Trask, Sydney. AU - Pullins, Shane E. AU - Helmstetter, Fred J. N1 - Funding Information: This work was supported by National Institute of Health (NIH) grants MH112141 and AG053854 (FJH) and startup funds from the College of Agricultural and Life Sciences and the College of Science at Virginia Tech (TJJ).May 26, 2016 · Graham D. L. et al.. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 10, 1029–1037 (2007). [Google Scholar] Graham D. L. et al.. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 65, 696–701 (2009). Kwapis JL, Jarome TJ, Gilmartin MR, Helmstetter FJ. Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. Neurobiol Learn Mem. 2012; 98:148–153. doi: 10.1016/j.nlm.2012.05.003. [PMC free article] [Google Scholar]Kwapis JL, Jarome TJ, Gilmartin MR, Helmstetter FJ. Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. Neurobiol Learn Mem. 2012; 98:148–153. doi: 10.1016/j.nlm.2012.05.003. [PMC free article] [Google Scholar]Thus, Per1 may independently function within the DH to regulate memory in addition to its known role in regulating the circadian system within the SCN. Per1 may therefore exert local diurnal control over memory consolidation within the DH. The circadian system influences many different biological processes, including memory performance.

Alaghband, Yasaman ; Kramár, Enikö ; Kwapis, Janine L. et al. / CREST in the nucleus accumbens core regulates cocaine conditioned place preference, cocaine-seeking behavior, and synaptic plasticity.

Quantitative real-time RT-PCR was performed to measure CREST expression following one-trial cocaine conditioning as previously described (López et al., 2016; White et al., 2016; Alaghband et al., 2017; Kwapis et al., 2017). Punches (0.5 mm) in the NAc were collected from 500 μm slices. All tissue was stored at −80°C until processing.Timothy J Jarome 1 , Janine L Kwapis , Wendy L Ruenzel , Fred J Helmstetter Affiliation 1 Department of Psychology, University of Wisconsin-Milwaukee …Janine L. Kwapis: Conceptualization, Writing - original draft, Writing - review & editing, Supervision, Funding acquisition. Declaration of Competing Interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Author links open overlay panel Alberto J. López a b c, Thekla J. Hemstedt a c, Yousheng Jia d, Philip H. Hwang a b c, Rianne R. Campbell a b c, Janine L. Kwapis a c, Andre O. White e, Om Chitnis a b c, Vanessa M. Scarfone f, Dina P. Matheos a b c, Gary Lynch b c d, Marcelo A. Wood a b cExampleOULTest Video: Video 1: ExampleOULTest.mpg. Title: Example Test session from OUL for scoring practice. This video is from an OUL test session with four young male C57BL/6J male mice run simultaneously. Two of these animals (the top right and bottom right boxes) were "No Update" animals and two animals each received a memory update (the mouse in the top left box had the right object ...Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined.The orphan nuclear receptor nurr1, a member of the hormone receptor superfamily for which a ligand has not yet been identified, is encoded by an immediate early gene that can be rapidly induced by different stimuli (Law et al. 1992; Scearce et al. 1993; Davis and Lau 1994; Mages et al. 1994; Murphy and Conneely 1997).This transcription factor is expressed predominantly in the brain (Law et al ...Kwapis, Janine L López, Alberto J et al. Publication Date 2017-11-01 DOI 10.1016/j.nlm.2017.09.001 Peer reviewed eScholarship.org Powered by the California Digital Library University of California. Distinct roles for the deacetylase domain of HDAC3 in theResearch The Kwapis Lab studies the molecular and epigenetic mechanisms that underlie long-term memory formation, storage, and updating. We want to understand the mechanisms that underlie memory and identify how these mechanisms are dysregulated during aging, leading to age-related memory impairments.Janine L. Kwapis and Marcelo A. Wood Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, 92697 Abstract Post-traumatic stress disorder (PTSD) and other anxiety disorders stemming from dysregulated fear memory are problematic and costly.

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Janine L. Kwapis, Ph.D. (she/her) principal investigator; The Paul Berg Early Career Professor in the Biological Sciences. Janine received her Ph.D. in Behavioral …Janine L. Kwapis Timothy J Jarome M. E. Lonergan F. Helmstetter. Biology, Psychology. Behavioral neuroscience. 2009; TLDR. The results indicate that PKMzeta inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory, which suggests that PKmzeta may only maintain select forms of memory in specific brain structures and does ...Janine L. Kwapis: Conceptualization, Methodology, Writing – original draft, Writing – review & editing, Supervision, Project administration, Funding acquisition. Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work ...Neurobiology of learning and memory 128, 103-109. , 2016. 114. 2016. Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the …Janine L Kwapis, 1, 2 Yasaman Alaghband, 1 Alberto J López, 1 André O White, 3 Rianne R Campbell, 1 Richard T Dang, 1 Diane Rhee, 1 Ashley V Tran, 1 Allison E Carl, 1 Dina P Matheos, 1 and Marcelo A Wood 1, 2, * Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...The research both for and against the idea that PKM ζ is a memory maintenance mechanism are outlined and a number of studies are proposed that would help to clarify the role of PKMζ in memory and define other mechanisms the brain may use to maintain memory. Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKM ζ ) in maintaining ...Janine L. Kwapis View These studies as a whole suggest that connectivity 498 between these regions, and not simply atrophy or brain volume, mediates circadian 499 phenotype and associated traits.Janine L. Kwapis. Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author. ….

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.Updating Procedures Can Reorganize the Neural Circuit Supporting a Fear Memory Janine L Kwapis1,2, Timothy J Jarome1,3, Nicole C Ferrara1 and Fred J Helmstetter*,1 1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.'Janine L Kwapis 1 , Timothy J Jarome 1 , Nicole C Ferrara 1 , Fred J Helmstetter 1 Affiliation 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. PMID: 28139682 PMCID: PMC5518901 DOI: 10.1038/npp.2017.23 Abstract Established memories undergo a period of vulnerability following retrieval, a process termed ...Janine L Kwapis 1 2 3 , Yasaman Alaghband 1 2 , Enikö A Kramár 1 2 , Alberto J López 1 2 , Annie Vogel Ciernia 4 , André O White 5 , Guanhua Shu 1 2 , Diane Rhee 1 2 , Christina M Michael 1 2 , Emilie Montellier 6 , Yu Liu 7 8 , Christophe N Magnan 7 8 , Siwei Chen 7 8 , Paolo Sassone-Corsi 6 , Pierre Baldi 7 8 , Dina P Matheos 1 2 ...Aug 20, 2018 · The work of Y.L., C.M., S.C., and P.B. was in part supported by NSF grant IIS- 1550705, DARPA grant D17AP00002, and NIH GM123558 to P.B. E.M. was supported by a long-term EMBO post-doctoral fellowship and an ARC Foundation award and work in the P.S.-C. lab was supported by grants from the National Institutes of Health, INSERM, and the Novo ... Destiny S. Wright, 1 Kasuni K. Bodinayake, 1 and Janine L. Kwapis 1, * Destiny S. Wright 1 Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA, USAAddress details of webmaster : Lt Col Johan Heuer Tel: +27 (0) 12 393 7030 [email protected]. Terms and Coditions | Links Terms and Coditions | LinksLauren Bellfy Janine L. Kwapis. Biology. International Journal of Molecular Sciences. 2020; TLDR. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails. Janine l. kwapis, Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this author. Destiny S. Wright, Destiny S. Wright., Janine L. Kwapis Timothy J Jarome M. E. Lonergan F. Helmstetter Biology, Psychology Behavioral neuroscience 2009 TLDR The results indicate that PKMzeta inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory, which suggests that ..., Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ..., Oct 10, 2018 · Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory. , Kwapis JL, Jarome TJ, Helmstetter FJ. The role of the medial prefrontal cortex in trace fear extinction. Learn Mem. 2015; 22 (1):39–46. [PMC free article] [Google Scholar] Kwapis JL, Jarome TJ, Lee JL, Gilmartin MR, Helmstetter FJ. Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala. Neurobiol Learn Mem. , Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,238,717 articles, preprints and more) (41,238,717 articles, preprints and more), Janine Kwapis, assistant professor of biology at Penn State, has been appointed as the first Paul Berg Early Career Professor in the Biological Sciences in recognition of her research contributions, teaching, and service to the Department of Biology and the Eberly College of Science.The professorship was created through an …, Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ..., Janine L. Kwapis Scilit Preprints.org Google Scholar Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA 16802, USA, Added Creator Janine L. Kwapis November 15, 2021 13:11 by Researcher Metadata Database. Published November 15, 2021 13:11 by Researcher Metadata Database. Updated February 28, 2022 22:44 ..., Janine L Kwapis, 1, 2 Yasaman Alaghband, 1 Alberto J López, 1 André O White, 3 Rianne R Campbell, 1 Richard T Dang, 1 Diane Rhee, 1 Ashley V Tran, 1 Allison E Carl, 1 Dina P Matheos, 1 and Marcelo A Wood 1, 2, * , The editors depend heavily on outside reviewers in forming opinions about papers submitted to eNeuro and would like to formally thank the following individuals for their help during the past year. Wickliffe C. Abraham Rochelle Ackerley Kirsten C. S. Adam Omar J. Ahmed Turgay Akay Allyson Alexander Hossein Aleyasin Topaz Altman Krishna Chaitanya Aluri Rachel M. Anderson William David Andrews ..., Janine L Kwapis; Timothy J Jarome; Nicole C Ferrara; Fred J Helmstetter; Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work ..., C.L. Bennett. Pages 44-57 View PDF. Article preview. select article Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI) ... Alexandria R. McKenna, ... Janine L. Kwapis. Pages ..., J Okombo, S Mok, T Qahash, T Yeo, J Bath, L Orchard, E Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, D Fidock, 2022, PLoS Pathogens on p. e1010926 Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites, Janine L Kwapis 1 2 , Yasaman Alaghband 3 , Ashley A Keiser 3 , Tri N Dong 3 , Christina M Michael 3 , Diane Rhee 3 , Guanhua Shu 3 , Richard T Dang 3 , Dina P Matheos 3 , Marcelo A Wood 3 Affiliations 1 Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University ..., Articles from the Special Issue on Recognizing James L. McGaugh's contributions to the neurobiology of learning and memory; Guest edited by Gina Quirarte and Paul Gold ... Chad A. Brunswick, ... Janine L. Kwapis. Article 107535 View PDF. Article preview. select article Elevated fear responses to threatening cues in rats with early life stress ..., Janine L. Kwapis (University of California Center for the Neurobiology of Learning and Memory University of California) Yasaman Alaghband (University of California Center for the Neurobiology of Learning and Memory) Enikö A. Kramár (University of California Center for the Neurobiology of Learning and Memory) Alberto J. López (University of ..., Janine L Kwapis. Affiliations. 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, United States. 2 Department of ..., Janine L. Kwapis Timothy J Jarome M. E. Lonergan F. Helmstetter. Biology, Psychology. Behavioral neuroscience. 2009; TLDR. The results indicate that PKMzeta inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory, which suggests that PKmzeta may only maintain select forms of memory in specific brain structures and does ..., Abstract. Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association.The NR2B subunit confers unique properties to the NMDAR and may differentially regulate these two fear memories., Neurobiology of learning and memory 128, 103-109. , 2016. 114. 2016. Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex. MR Gilmartin, JL Kwapis, FJ Helmstetter. Neurobiology of learning and memory 97 (4), 452-464., The next day, all animals were tested for their responses to the contextual and auditory cues. We found a main effect for drug on the context test (F (2,24) = 6.626, P = 0.005) (Fig. 2A).Fisher LSD post hoc tests revealed significant impairments in retention for the training context in animals that received either 100 μM (P = 0.026) or 200 μM (P = 0.002) concentrations of IU1 relative to ..., The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ..., Janine L Kwapis; Timothy J Jarome; The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to ..., Bellfy L, Kwapis JL. Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. International Journal of Molecular Sciences. 21. PMID 32916796 DOI: 10.3390/ijms21186580 : 0.887: 2020: Wright DS, Bodinayake KK, Kwapis JL. Investigating Memory Updating in Mice Using the Objects in Updated Locations Task. Current Protocols in Neuroscience ..., Janine Kwapis. The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle..., Oct 12, 2022 · View ORCID Profile Lauren Bellfy, View ORCID Profile Chad W. Smies, Alicia R. Bernhardt, View ORCID Profile Kasuni K. Bodinayake, Aswathy Sebastian, Emily M. Stuart, Destiny S. Wright, Chen-Yu Lo, Shoko Murakami, View ORCID Profile Hannah M. Boyd, Megan J. von Abo, View ORCID Profile Istvan Albert, View ORCID Profile Janine L. Kwapis , Oct 11, 2019 · Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process and adaptation of fear for each avoidance behavior ... , Hannah M. Boyd1, Megan J. von Abo1, Istvan Albert2,3, Janine L. Kwapis1,* 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA 2 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA 3 Department of Biochemistry and Molecular Biology,, Alzheimer's Disease affects 5.4 million Americans [1] and by 2030, approximately 13.8 million people 65 or older are projected to have the disease [2]. Even more individuals will experience normal age..., Yasaman Alaghband, Enikö Kramár, Janine L. Kwapis, Earnest S. Kim, Thekla J. Hemstedt, Alberto J. López, André O. White, Amni Al-Kachak, Osasumwen V. Aimiuwu ..., The research both for and against the idea that PKM ζ is a memory maintenance mechanism are outlined and a number of studies are proposed that would help to clarify the role of PKMζ in memory and define other mechanisms the brain may use to maintain memory. Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKM ζ ) in maintaining ...